abstract：:Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the prof...

journal_title：Medical hypotheses

authors： Eastwood JA,Taylor DA,Johnson BD,Resende M,Sharaf BL,Ahmed B,Minissian M,Shufelt C,Merz NB

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Cardiac resynchronization therapy (CRT) or biventricular pacing (BIVP) has become a common procedure for the treatment of ventricular dyssynchrony in patients with heart failure, particularly in those with bundle branch block patterns (QRS durations >150ms) on the electrocardiogram (ECG). However, a large ...

journal_title：Medical hypotheses

authors： Scherlag BJ,Papaila A

更新日期：2017-11-01 00:00:00

abstract：:Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and a...

journal_title：Medical hypotheses

authors： More N,Kapusetti G

更新日期：2017-10-01 00:00:00

abstract：:Early detection of mycoplasma infection is crucial for saving precious often irreplaceable data from the tissues of patients. Mycoplasma infections cause diseases in the upper and lower respiratory tracts, urethritis in men resulting in painful dysuria, urgency and urethral discharge. Cough, fever, headache, urethriti...

journal_title：Medical hypotheses

authors： Talas L,Banfalvi G,Fidrus E,Szigeti ZM,Nagy G

更新日期：2017-10-01 00:00:00

abstract：:The 2013 American Heart Association Blood Cholesterol Guidelines increased the number of patients recommended for statin therapy in the United States to 56million. Two common statin side effects are muscle pain, referred to as "statin-associated muscle symptoms", and increased risk for new onset type-2-diabetes mellit...

journal_title：Medical hypotheses

authors： Carris NW,Tipparaju SM,Magness DJ,Chapalamadugu KC,Magness RR

更新日期：2017-09-01 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...

journal_title：Medical hypotheses

authors： Celiker H

更新日期：2017-09-01 00:00:00

abstract：:Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy...

journal_title：Medical hypotheses

authors： Schulpen TWJ

更新日期：2017-09-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cel...

journal_title：Medical hypotheses

authors： Neuman T,David K,Cooper D,Strair R

更新日期：2017-07-01 00:00:00

abstract：:The authors support the hypothesis that a causative agent in Parkinson's disease (PD) might be either fungus or bacteria with fungus-like properties - Actinobacteria, and that their spores may serve as 'infectious agents'. Updated research and the epidemiology of PD suggest that the disease might be induced by environ...

journal_title：Medical hypotheses

authors： Berstad K,Berstad JER

更新日期：2017-07-01 00:00:00

abstract：:The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a ...

journal_title：Medical hypotheses

authors： Rukhlenko OS,Guria GT,Vorobiev AI

更新日期：2017-07-01 00:00:00

abstract：:Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and ...

journal_title：Medical hypotheses

authors： Chen J,Zhou J,Kelly M,Holbein BE,Lehmann C

更新日期：2017-06-01 00:00:00

abstract：:Local-regional relapse is the main recurrence pattern of the carcinoma in gut, and leads to poor prognosis. With the development of the total mesorectal and complete mesocolic excision (TME/CME), the local relapse rate of colorectal cancer has significantly decreased. People attributed it to the improvement of lymphad...

journal_title：Medical hypotheses

authors： Shen J,Xie D,Tong Y,Gong J

更新日期：2017-06-01 00:00:00

abstract：:As a type of primary open-angle glaucoma, normal-tension glaucoma (NTG) is a health problem that manifests itself with low intraocular pressure (IOP) levels and preserves its importance for public health care. In population-based screenings, which take the IOP levels of 21mmHg as a cut-off for the diagnosis of glaucom...

journal_title：Medical hypotheses

authors： Atalay K,Kaldirim Erdogan H,Kirgiz A,Asik Nacaroglu S

更新日期：2017-06-01 00:00:00

abstract：:Cannabinoid hyperemesis syndrome (CHS), a variant of cyclic vomiting syndrome, is an enigmatic and challenging clinical disorder. As cannabis legalization, use, and potency has increased worldwide over the past decade, so has the prevalence of CHS. These patients often require acute care and inpatient treatment for re...

journal_title：Medical hypotheses

authors： Richards JR

更新日期：2017-06-01 00:00:00

abstract：:HLA-G is a nonclassical HLA immunotolerogenic molecule expressed in different human cell types. Successful embryo implantation is a consequence of information exchange between the uterus and the blastocyst. It is widely accepted that HLA-G expression by the fetus promotes the establishment of several mechanisms that, ...

journal_title：Medical hypotheses

authors： Kaminski V,Ellwanger JH,Chies JAB

更新日期：2017-05-01 00:00:00

abstract：:Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a numb...

journal_title：Medical hypotheses

authors： Truscelli G,Tanzilli G,Viceconte N,Dominici M,Arrivi A,Sommariva L,Granatelli A,Gaudio C,Mangieri E

更新日期：2017-05-01 00:00:00

abstract：:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. ...

journal_title：Medical hypotheses

authors： Brenner SR

更新日期：2017-05-01 00:00:00

abstract：:Melasma is an acquired disorder of pigmentation that presents with asymptomatic symmetric darkening of the face. The pathogenesis of this condition is multifactorial and influenced by several factors including female sex hormones, genetic predisposition and ultraviolet light exposure. The management of melasma is usua...

journal_title：Medical hypotheses

authors： Cohen PR

更新日期：2017-04-01 00:00:00

abstract：:A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...

journal_title：Medical hypotheses

authors： Łuczkiewicz P,Daszkiewicz K,Chróścielewski J,Witkowski W,Kuik L

更新日期：2017-04-01 00:00:00

abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...

journal_title：Medical hypotheses

authors： Tonello L,Cocchi M,Gabrielli F,Tuszynski JA

更新日期：2017-04-01 00:00:00

abstract：:Trigeminal neuralgia is a painful condition that causes great discomfort. Although this disease has been known for more than 1000years, there is still no consensus on its underlying mechanism or treatment. Many hypotheses have been reported to explain the cause and nature of trigeminal neuralgia. These include theorie...

journal_title：Medical hypotheses

authors： Peker S,Sirin A

更新日期：2017-03-01 00:00:00

abstract：:Physical inactivity and a low maximal aerobic capacity (VO2max) strongly predict morbidity and mortality in patients with type 2 diabetes (T2D). Patients with T2D have a reduced VO2max when compared with healthy individuals of similar age, weight, and physical activity levels, and this lower aerobic capacity is usuall...

journal_title：Medical hypotheses

authors： Leone RJ,Lalande S

更新日期：2017-03-01 00:00:00

abstract：:So far, the pathogenesis of Alzheimer's disease (AD) has not been clarified, nor has patient therapy been satisfactory. Although inheritance dominates the less frequent early-onset AD in young and middle-aged individuals, environmental and immunogenetic factors have been identified in the most frequently occurring lat...

journal_title：Medical hypotheses

authors： Laumbacher B,Fellerhoff-Loesch B,Wank R

更新日期：2017-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppr...

journal_title：Medical hypotheses

authors： Damar U,Gersner R,Johnstone JT,Schachter S,Rotenberg A

更新日期：2017-02-01 00:00:00

abstract：:Recent studies suggest that blood-borne metabolites of gut microbiota, such as trimethylamine N-oxide (TMAO) are involved in the aetiology of cardiovascular diseases and may serve as markers of cardiovascular risk. To enter the bloodstream the microbiota-derived molecules need to pass the gut-blood barrier (GBB). The ...

journal_title：Medical hypotheses

authors： Ufnal M,Pham K

更新日期：2017-01-01 00:00:00

abstract：:Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission. In this class of mood disturbances, a unipolar major depressive disorder known as winter depression is common in populations living in northern latitudes far from the equator. Winter...

journal_title：Medical hypotheses

authors： Pereira JC Jr,Pradella Hallinan M,Alves RC

更新日期：2017-01-01 00:00:00

abstract：:The treatment and prevention of migraine within the last decade has become largely pharmacological. While there is little doubt that the advent of drugs (e.g. triptans) has helped many migraine sufferers to lead a normal life, there is still little knowledge with respect to the factors responsible for precipitating a ...

journal_title：Medical hypotheses

authors： Kokavec A

更新日期：2016-12-01 00:00:00

abstract：:Dyslipidemia is a common pathology throughout the industrialized world, and HMG-CoA reductase inhibitors (statins) are often administered to treat elevated lipid levels. Substantial concern has been raised regarding the aggressive clinical lowering of cholesterol, particularly in light of a growing body of research li...

journal_title：Medical hypotheses

authors： Gendle MH

更新日期：2016-12-01 00:00:00

abstract：:Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes tak...

journal_title：Medical hypotheses

authors： Tong Y,Zhou YL,Wang YX,Zhao PQ,Wang ZY

更新日期：2016-12-01 00:00:00

abstract：:Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberration...

journal_title：Medical hypotheses

authors： DeSoto MC

更新日期：2016-11-01 00:00:00

abstract：:Geographic patterns with diminishing rates from north to south toward the equator have been described for a number of diseases, putatively related largely to "western" lifestyle. Among these the inflammatory bowel diseases; Crohn's (CD) and Ulcerative colitis (UC) have been prominent in sharing distributions with a nu...

journal_title：Medical hypotheses

authors： Szilagyi A,Xue X

更新日期：2016-11-01 00:00:00

abstract：:Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...

journal_title：Medical hypotheses

authors： Singh V

更新日期：2016-10-01 00:00:00

abstract：:Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis ...

journal_title：Medical hypotheses

authors： Sarkar S,Chopra S,Rohit MK,Banerjee D,Chakraborti A

更新日期：2016-10-01 00:00:00

abstract：:An unconventional interaction between a patient and parasites was recently reported, in which parasitic cells invaded host's tissues, establishing several tumors. This finding raises various intriguing hypotheses on unpredicted forms of interplay between a patient and infecting parasites. Here we present four unusual ...

journal_title：Medical hypotheses

authors： de Souza TA,de Carli GJ,Pereira TC

更新日期：2016-09-01 00:00:00

abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...

journal_title：Medical hypotheses

authors： Roper WG

更新日期：2016-09-01 00:00:00

abstract：:Cardiovascular calcification (CVC) associated with conditions such as ageing, diabetes or renal impairment, results from the deposition of hydroxyapatite in the endothelium or media of blood vessels. Key medical management options are directed towards controlling plasma calcium and phosphate concentrations (e.g. parat...

journal_title：Medical hypotheses

authors： Joubert P,Ketteler M,Salcedo C,Perello J

更新日期：2016-09-01 00:00:00

abstract：:Random connection weight disturbances within an assembly of artificial neural networks (ANN) drive a progression of activation patterns that are tantamount to the memories and ideas nucleating within the brain's cortex. The numerical evaluation of these pattern-based notions by another, more placid system of ANNs gove...

journal_title：Medical hypotheses

authors： Thaler SL

更新日期：2016-09-01 00:00:00

abstract：:Diabetes mellitus, a metabolic disorder with significant global health care burden, causes chronic microvascular and macrovascular complications that still comprise a therapeutic challenge. Angiotensin-(1-7), a heptapeptide with vasodilatory properties, has been found to restore vascular reactivity and endothelial cel...

journal_title：Medical hypotheses

authors： Kibel A

更新日期：2016-08-01 00:00:00

abstract：:Immunotherapy has attracted attention as a novel treatment modality for malignant melanoma. Although the use of immunotherapy in metastatic melanoma has shown promising results, there remains a lack of predictive biomarkers indicating treatment benefit from immunotherapy. There is growing evidence suggesting that micr...

journal_title：Medical hypotheses

authors： Kubecek O,Trojanova P,Molnarova V,Kopecky J

更新日期：2016-08-01 00:00:00